Human Skin Aryl Hydrocarbon Hydroxylase
نویسندگان
چکیده
منابع مشابه
Seasonal variation of aryl hydrocarbon hydroxylase activity in human lymphocytes.
A seasonal variation was observed when aryl hydrocarbon hydroxylase (AHH) activity was measured in the cultured lymphocytes of 977 donors over a period of 2 1/2 years. The variation was strongest in AHH activity induced by 3-methylcholanthrene and was less apparent for AHH activity in lymphocytes grown without any inducer. The period of the seasonal variation is 1 year, and maximal induced AHH ...
متن کاملGenetic Regulation of Aryl Hydrocarbon Hydroxylase Induction
In the inbred C57BL/6N mouse, aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons increases rapidly in the neonatal period; this response to these pharmacological, exogenous compounds does not appear in the DBA/2N, NZW/BLN, or NZB/BLN strains. The development of the constitutive hydroxylase activity in the neonatal period is the same in all four strains. Small differences in pH op...
متن کاملGenetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice.
Inbred strains of mice show differential skin inflammatory reactivity following the topical application of polycyclic hydrocarbons. Strains also differ in the extent to which hepatic aryl hydrocarbon hydroxylase activity is induced by these compounds. Differential inflammatory response and hydroxylase inducibility are genetically controlled by alleles at the In and Ahh loci, respectively. Genet...
متن کاملGonadal aryl hydrocarbon hydroxylase in rats and mice.
Rat and mouse gonadal aryl hydrocarbon hydroxylase (AHH) activity was measured and characterized in control and 3-methylcholanthrene (MC)-treated animals. The ovarian AHH activity increased 2to 3-fold in SpragueDawley, Lewis, and Brown-Norway rats following MC treatment. The same treatment decreased the testicular AHH activity in Sprague-Dawley rats. The induction of AHH activity after MC admin...
متن کاملInduction of aryl hydrocarbon hydroxylase in human pulmonary alveolar macrophages by cigarette smoking.
Pulmonary alveolar macrophages were obtained from healthy volunteers by saline pulmonary lavage, and aryl hydrocarbon hydroxylase was measured in the cells. Enzyme activity was low in cells from five nonsmokers with a mean of 0.008+/-0.004 U/10(6) cells. Cells obtained from nine cigarette smokers contained higher enzyme levels, with a mean of 0.095+/-0.024 U/10(6) cells. A former cigarette smok...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1978
ISSN: 0021-9738
DOI: 10.1172/jci109211